8G1Q
Co-crystal structure of Compound 1 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB
Summary for 8G1Q
Entry DOI | 10.2210/pdb8g1q/pdb |
Related | 8G1P |
Descriptor | Transcription activator BRG1, Elongin-B, Elongin-C, ... (8 entities in total) |
Functional Keywords | ternary complex, protacs, transcription, gene regulation |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 56767.95 |
Authors | Ghimire Rijal, S.,Wurz, R.P.,Vaish, A. (deposition date: 2023-02-02, release date: 2023-07-26, Last modification date: 2023-08-30) |
Primary citation | Wurz, R.P.,Rui, H.,Dellamaggiore, K.,Ghimire-Rijal, S.,Choi, K.,Smither, K.,Amegadzie, A.,Chen, N.,Li, X.,Banerjee, A.,Chen, Q.,Mohl, D.,Vaish, A. Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation. Nat Commun, 14:4177-4177, 2023 Cited by PubMed: 37443112DOI: 10.1038/s41467-023-39904-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.73 Å) |
Structure validation
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