8FTJ

Crystal structure of human NEIL1 (P2G (242K) C(delta)100) glycosylase bound to DNA duplex containing urea

Summary for 8FTJ

• Entry DOI: 10.2210/pdb8ftj/pdb
• Descriptor: Endonuclease 8-like 1, DNA (5'-D(*CP*GP*TP*CP*CP*AP*UDV*GP*TP*CP*TP*AP*CP)-3'), DNA (5'-D(*TP*AP*GP*AP*CP*AP*TP*GP*GP*AP*CP*GP*G)-3'), ... (6 entities in total)
• Functional Keywords: base-excision repair enzyme, dna glycosylase, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 41994.96

Authors

Tomar, R.,Sharma, P.,Harp, J.M.,Egli, M.,Stone, M.P. (deposition date: 2023-01-12, release date: 2023-04-26, Last modification date: 2024-05-01)

• Primary citation: Tomar, R.,Minko, I.G.,Sharma, P.,Kellum, A.H.,Lei, L.,Harp, J.M.,Iverson, T.M.,Lloyd, R.S.,Egli, M.,Stone, M.P.; Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase.; Nucleic Acids Res., 51:3754-3769, 2023; PubMed: 37014002; DOI: 10.1093/nar/gkad164

Experimental method

X-RAY DIFFRACTION (2.3 Å)