8FLW
Cryo-EM Structure of PGT145 DU303 Fab in complex with BG505 DS-SOSIP.664
Summary for 8FLW
Entry DOI | 10.2210/pdb8flw/pdb |
EMDB information | 29288 |
Descriptor | PGT145 DU303 Heavy, PGT145 DU303 Light, Envelope glycoprotein gp41, ... (8 entities in total) |
Functional Keywords | cd4, hiv-1, sosip, vaccine, immune system, llama, v2 apex, therapeutic, viral protein |
Biological source | Homo sapiens More |
Total number of polymer chains | 8 |
Total formula weight | 285871.07 |
Authors | Gorman, J.,Kwong, P.D. (deposition date: 2022-12-22, release date: 2023-05-31, Last modification date: 2023-07-26) |
Primary citation | Holt, G.T.,Gorman, J.,Wang, S.,Lowegard, A.U.,Zhang, B.,Liu, T.,Lin, B.C.,Louder, M.K.,Frenkel, M.S.,McKee, K.,O'Dell, S.,Rawi, R.,Shen, C.H.,Doria-Rose, N.A.,Kwong, P.D.,Donald, B.R. Improved HIV-1 neutralization breadth and potency of V2-apex antibodies by in silico design. Cell Rep, 42:112711-112711, 2023 Cited by PubMed: 37436900DOI: 10.1016/j.celrep.2023.112711 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.58 Å) |
Structure validation
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