8FLW
Cryo-EM Structure of PGT145 DU303 Fab in complex with BG505 DS-SOSIP.664
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | PGT145 DU303 Heavy | polymer | 252 | 27310.4 | 1 | Homo sapiens | ||
| 2 | B (L) | PGT145 DU303 Light | polymer | 219 | 23953.8 | 1 | Homo sapiens | ||
| 3 | C, D, F (A, B, F) | Envelope glycoprotein gp41 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S6) | Human immunodeficiency virus 1 | Env polyprotein |
| 4 | E, G, H (C, G, I) | Envelope glycoprotein gp120 | polymer | 481 | 54086.3 | 3 | UniProt (Q2N0S6) | Human immunodeficiency virus 1 | Env polyprotein |
| 5 | AA, BA, EA, I, K... (a, b, e, D, J...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 14 | In PDB GlyTouCan (G42666HT) | |||
| 6 | J, N, Q, X (E, N, Q, X) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 4 | In PDB GlyTouCan (G56014GC) | |||
| 7 | CA, DA, O, R, V (c, d, O, R, V) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 5 | In PDB GlyTouCan (G15407YE) | |||
| 8 | AB, BB, CB, DB, EB... (G, A, I, B, C...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 35 | Chemie (NAG) |
Sequence modifications
A, B, F: 512 - 664 (UniProt: Q2N0S6)
C, G, I: 31 - 513 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Pro 559 | Ile 556 | conflict |
| Cys 605 | Thr 602 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Cys 201 | Ile 200 | conflict |
| Asn 332 | Thr 330 | conflict |
| Cys 433 | Ala 430 | conflict |
| Cys 501 | Ala 498 | conflict |
| Arg 509 | Glu 506 | conflict |
| Arg 510 | Lys 507 | conflict |
| Arg 512 | Ala 509 | conflict |
| Arg 513 | Val 510 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 264962.6 | |
| Branched | Number of molecules | 23 |
| Total formula weight | 13166.2 | |
| Non-Polymers* | Number of molecules | 35 |
| Total formula weight | 7742.3 | |
| All* | Total formula weight | 285871.1 |
