8FE2
Structure of J-PKAc chimera complexed with Aplithianine A
Summary for 8FE2
Entry DOI | 10.2210/pdb8fe2/pdb |
Descriptor | DnaJ homolog subfamily B member 1, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 6-[(6M)-6-(1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-9H-purine, ... (4 entities in total) |
Functional Keywords | protein kinase a, fibrolamellar hepatocellular carcinoma, natural product, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 100235.42 |
Authors | Du, L.,Wilson, B.A.P.,Li, N.,Dalilian, M.,Wang, D.,Martinez Fiesco, J.A.,Smith, E.A.,Wamiru, A.,Goncharova, E.I.,Zhang, P.,O'Keefe, B.R. (deposition date: 2022-12-05, release date: 2023-10-18, Last modification date: 2024-05-01) |
Primary citation | Du, L.,Wilson, B.A.P.,Li, N.,Shah, R.,Dalilian, M.,Wang, D.,Smith, E.A.,Wamiru, A.,Goncharova, E.I.,Zhang, P.,O'Keefe, B.R. Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases. J.Nat.Prod., 86:2283-2293, 2023 Cited by PubMed: 37843072DOI: 10.1021/acs.jnatprod.3c00394 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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