8FDX
AGF271 and GAR in complex with human recombinant GARFTase, ligase, purine biosynthesis, transfers formyl group from 10-formyl tetrahydrofolate to glycinamide ribonucleotide (GAR) to form tetrahydrofolate and formyl GAR
Summary for 8FDX
Entry DOI | 10.2210/pdb8fdx/pdb |
Descriptor | Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[3-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)propyl]thiophene-2-carbonyl}-L-glutamic acid, ... (4 entities in total) |
Functional Keywords | garftase, ligase, purine biosynthesis, monomer |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 23558.81 |
Authors | Nyman, M.C.,Wong-Roushar, J.,Dann III, C.E. (deposition date: 2022-12-05, release date: 2023-05-10, Last modification date: 2023-10-25) |
Primary citation | Tong, N.,Wong-Roushar, J.,Wallace-Povirk, A.,Shah, Y.,Nyman, M.C.,Katinas, J.M.,Schneider, M.,O'Connor, C.,Bao, X.,Kim, S.,Li, J.,Hou, Z.,Matherly, L.H.,Dann 3rd, C.E.,Gangjee, A. Multitargeted 6-Substituted Thieno[2,3- d ]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism. Acs Pharmacol Transl Sci, 6:748-770, 2023 Cited by PubMed: 37200803DOI: 10.1021/acsptsci.3c00020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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