8F9Z
Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with NBD-14204, an HIV-1 gp120 antagonist
Summary for 8F9Z
Entry DOI | 10.2210/pdb8f9z/pdb |
Descriptor | HIV-1 gp120 core, 2-acetamido-2-deoxy-beta-D-glucopyranose, (5M)-N-{(1S)-2-amino-1-[5-(hydroxymethyl)-1,3-thiazol-2-yl]ethyl}-5-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrrole-2-carboxamide, ... (5 entities in total) |
Functional Keywords | hiv-1, nbd-14204, small molecules, cd4-gp120 binding inhibitor, antagonist, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 41137.32 |
Authors | Kwon, Y.D.,Kwong, P.D. (deposition date: 2022-11-25, release date: 2023-01-11, Last modification date: 2023-09-20) |
Primary citation | Curreli, F.,Kwon, Y.D.,Nicolau, I.,Burgos, G.,Altieri, A.,Kurkin, A.V.,Verardi, R.,Kwong, P.D.,Debnath, A.K. Antiviral Activity and Crystal Structures of HIV-1 gp120 Antagonists. Int J Mol Sci, 23:-, 2022 Cited by PubMed: 36555641DOI: 10.3390/ijms232415999 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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