8F4V
Alpha7 nicotinic acetylcholine receptor intracellular and transmembrane domains bound to ivermectin in a desensitized state
Summary for 8F4V
Entry DOI | 10.2210/pdb8f4v/pdb |
NMR Information | BMRB: 31058 |
Descriptor | Neuronal acetylcholine receptor subunit alpha-7, (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside (2 entities in total) |
Functional Keywords | nicotinic acetylcholine receptor, transmembrane and intracellular domain, desensitized state, ivermectin, membrane protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 5 |
Total formula weight | 153534.36 |
Authors | Bondarenko, V.,Chen, Q.,Tang, P. (deposition date: 2022-11-11, release date: 2023-02-22, Last modification date: 2024-05-15) |
Primary citation | Bondarenko, V.,Chen, Q.,Singewald, K.,Haloi, N.,Tillman, T.S.,Howard, R.J.,Lindahl, E.,Xu, Y.,Tang, P. Structural Elucidation of Ivermectin Binding to alpha 7nAChR and the Induced Channel Desensitization. Acs Chem Neurosci, 14:1156-1165, 2023 Cited by PubMed: 36821490DOI: 10.1021/acschemneuro.2c00783 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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