8F4V
Alpha7 nicotinic acetylcholine receptor intracellular and transmembrane domains bound to ivermectin in a desensitized state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Neuronal acetylcholine receptor subunit alpha-7 | polymer | 272 | 29831.8 | 5 | UniProt (P36544) Pfam (PF02932) | Homo sapiens (human) | |
| 2 | F, G, H, I, J (A, B, C, D) | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside | non-polymer | 875.1 | 5 | Chemie (IVM) PubChem (23307238) PubChem (23307262) PubChem (177678855) PubChem (16760011) PubChem (44393100) PubChem (21584398) PubChem (23307215) PubChem (42648499) PubChem (44306127) PubChem (45114068) PubChem (66509061) PubChem (71308642) PubChem (53384911) PubChem (73438913) PubChem (56603652) PubChem (57182275) PubChem (73952278) PubChem (58594796) PubChem (59707377) PubChem (66577025) PubChem (70678372) PubChem (177065624) PubChem (177678952) PubChem (51025) PubChem (156069) PubChem (71749648) PubChem (73265241) PubChem (73357349) PubChem (73952283) PubChem (73952837) PubChem (74764330) PubChem (91407038) PubChem (3085416) PubChem (90479776) PubChem (90908120) PubChem (4330618) PubChem (118476986) PubChem (6419971) PubChem (6427057) PubChem (6440492) PubChem (6450358) PubChem (122172888) PubChem (6603890) PubChem (123132485) PubChem (6857963) PubChem (6914288) PubChem (6713922) PubChem (123456077) PubChem (6071412) PubChem (124870644) PubChem (124870718) PubChem (124929025) PubChem (124929026) PubChem (124929023) PubChem (125528694) PubChem (125528697) PubChem (125528696) PubChem (126963352) PubChem (6321424) PubChem (129010219) PubChem (129606809) PubChem (6604429) PubChem (6912779) PubChem (133562698) PubChem (112547093) PubChem (118477994) PubChem (11957587) PubChem (138106966) PubChem (139031854) PubChem (139594279) PubChem (145997404) PubChem (124870719) PubChem (124870720) PubChem (146159550) PubChem (124917050) PubChem (124917051) PubChem (124917052) PubChem (124918216) PubChem (124929024) PubChem (155970341) PubChem (155982218) PubChem (156599123) PubChem (162935621) PubChem (162935625) PubChem (162935623) PubChem (162935627) PubChem (125528695) PubChem (164724784) PubChem (168268469) PubChem (168312921) PubChem (171136628) PubChem (171689455) PubChem (172012500) PubChem (172878361) PubChem (172898004) PubChem (173492688) PubChem (173479738) PubChem (173174423) PubChem (175736172) PubChem (175683861) PubChem (129428148) PubChem (134814451) PubChem (135391144) PubChem (137700388) PubChem (140604781) PubChem (160897442) PubChem (162935622) PubChem (162935624) PubChem (162935626) PubChem (164186531) PubChem (168311793) PubChem (168313290) PubChem (168314662) PubChem (171378396) PubChem (173032036) PubChem (175764533) |
Sequence modifications
A, B, C, D, E: 209 - 474 (UniProt: P36544)
| PDB | External Database | Details |
|---|---|---|
| Ser 203 | - | expression tag |
| Asn 204 | - | expression tag |
| Ala 205 | - | expression tag |
| Glu 206 | - | expression tag |
| Glu 207 | - | expression tag |
| Glu 208 | - | expression tag |
| Ser 263 | Ala 285 | engineered mutation |
| Ser 268 | Val 290 | engineered mutation |
| Ser 270 | Leu 292 | engineered mutation |
| Glu 474 | Ala 496 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 149158.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 4375.5 | |
| All* | Total formula weight | 153534.4 |
