8F4A
Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with chlorhexidine
Summary for 8F4A
Entry DOI | 10.2210/pdb8f4a/pdb |
Descriptor | N-acetyltransferase Eis, GLYCEROL, 1-[6-[azanylidene-[[azanylidene-[[(4-chlorophenyl)amino]methyl]-$l^{4}-azanyl]methyl]-$l^{4}-azanyl]hexyl]-3-[~{N}-(4-chlorophenyl)carbamimidoyl]guanidine, ... (4 entities in total) |
Functional Keywords | drug resistance, inhibitor, acetylation, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mycobacterium tuberculosis H37Rv |
Total number of polymer chains | 1 |
Total formula weight | 46596.65 |
Authors | Pang, A.H.,Punetha, A.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2022-11-10, release date: 2023-02-08, Last modification date: 2023-10-25) |
Primary citation | Pang, A.H.,Green, K.D.,Punetha, A.,Thamban Chandrika, N.,Howard, K.C.,Garneau-Tsodikova, S.,Tsodikov, O.V. Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs. Biochemistry, 62:710-721, 2023 Cited by PubMed: 36657084DOI: 10.1021/acs.biochem.2c00658 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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