8F1F
Structure of K48-linked tri-ubiquitin in complex with cyclic peptide
Summary for 8F1F
Entry DOI | 10.2210/pdb8f1f/pdb |
Descriptor | Ubiquitin, Non-proteinogenic cyclic peptide (inhibitor), GLYCEROL, ... (7 entities in total) |
Functional Keywords | complex, therapeutic peptide, lys48-linked polyubiquitin, macrocyclic peptide, inhibitor of ubiquitin signaling, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 55291.38 |
Authors | Lubkowski, J.,Fushman, D.,Lemma, B. (deposition date: 2022-11-05, release date: 2023-11-01, Last modification date: 2023-11-15) |
Primary citation | Lemma, B.,Zhang, D.,Vamisetti, G.B.,Wentz, B.G.,Suga, H.,Brik, A.,Lubkowski, J.,Fushman, D. Mechanism of selective recognition of Lys48-linked polyubiquitin by macrocyclic peptide inhibitors of proteasomal degradation. Nat Commun, 14:7212-7212, 2023 Cited by PubMed: 37938554DOI: 10.1038/s41467-023-43025-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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