8F1F

Structure of K48-linked tri-ubiquitin in complex with cyclic peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, a	Ubiquitin	polymer	77	8691.9	2	UniProt (P0CG47) Pfam (PF00240) In PDB	Homo sapiens (human)
2	B, b	Ubiquitin	polymer	76	8576.8	2	UniProt (P0CG47) Pfam (PF00240) In PDB	Homo sapiens (human)
3	C, c	Ubiquitin	polymer	76	8604.8	2	UniProt (P0CG47) Pfam (PF00240) In PDB	Homo sapiens (human)
4	1, 2	Non-proteinogenic cyclic peptide (inhibitor)	polymer	14	1487.7	2		Homo sapiens
5	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	B, b	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	2	Chemie (EPE)
7		water	water		18.0	299	Chemie (HOH)

Sequence modifications

A, a: 1 - 76 (UniProt: P0CG47)

PDB	External Database	Details
Asp 77	-	insertion

C, c: 1 - 76 (UniProt: P0CG47)

PDB	External Database	Details
Arg 48	Lys 48	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	54722.7
Non-Polymers*	Number of molecules	3
	Total formula weight	568.7
All*	Total formula weight	55291.4

*Water molecules are not included.