8EDH
Identification of a class of WNK isoform-specific inhibitors through high-throughput screening
Summary for 8EDH
| Entry DOI | 10.2210/pdb8edh/pdb |
| Descriptor | Serine/threonine-protein kinase WNK3, ethyl 1-(5,7-dimethoxy-4-methylquinolin-2-yl)piperidine-4-carboxylate (3 entities in total) |
| Functional Keywords | inhibitor, wnk3, kinase, complex, transferase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 67634.29 |
| Authors | Akella, R.,Goldsmith, E.J. (deposition date: 2022-09-04, release date: 2023-03-01, Last modification date: 2023-10-25) |
| Primary citation | Chlebowicz, J.,Akella, R.,Humphreys, J.M.,He, H.,Kannangara, A.R.,Wei, S.,Posner, B.,Goldsmith, E.J. Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening. Drug Des Devel Ther, 17:93-105, 2023 Cited by PubMed: 36712947DOI: 10.2147/DDDT.S389461 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.111 Å) |
Structure validation
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