8EDH
Identification of a class of WNK isoform-specific inhibitors through high-throughput screening
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Serine/threonine-protein kinase WNK3 | polymer | 292 | 33637.9 | 2 | UniProt (Q9BYP7) Pfam (PF00069) In PDB | Homo sapiens (human) | Protein kinase lysine-deficient 3,Protein kinase with no lysine 3 |
| 2 | A | ethyl 1-(5,7-dimethoxy-4-methylquinolin-2-yl)piperidine-4-carboxylate | non-polymer | 358.4 | 1 | Chemie (WGK) | |||
| 3 | water | water | 18.0 | 158 | Chemie (HOH) |
Sequence modifications
A, C: 118 - 409 (UniProt: Q9BYP7)
| PDB | External Database | Details |
|---|---|---|
| Ala 308 | Ser 308 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67275.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 358.4 | |
| All* | Total formula weight | 67634.3 |
