8EAE
Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppG(2,5)pI
Summary for 8EAE
Entry DOI | 10.2210/pdb8eae/pdb |
Descriptor | Cyclic GMP-AMP synthase, Palindromic DNA18, [[(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate, ... (6 entities in total) |
Functional Keywords | transferase-dna complex, cgas, pppg(2, 5)pi, immune system, transferase/dna |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 109225.09 |
Authors | |
Primary citation | Wu, S.,Gabelli, S.B.,Sohn, J. The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS. Nat Commun, 15:4012-4012, 2024 Cited by PubMed: 38740774DOI: 10.1038/s41467-024-48365-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.56 Å) |
Structure validation
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