8E5A
Human L-type voltage-gated calcium channel Cav1.3 treated with 1.4 mM Sofosbuvir at 3.3 Angstrom resolution
Summary for 8E5A
Entry DOI | 10.2210/pdb8e5a/pdb |
EMDB information | 27908 |
Descriptor | Voltage-dependent L-type calcium channel subunit alpha-1D, Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent L-type calcium channel subunit beta-3, ... (8 entities in total) |
Functional Keywords | cav1.3, channels, calcium ion-selective, transport protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 427972.21 |
Authors | |
Primary citation | Yao, X.,Gao, S.,Wang, J.,Li, Z.,Huang, J.,Wang, Y.,Wang, Z.,Chen, J.,Fan, X.,Wang, W.,Jin, X.,Pan, X.,Yu, Y.,Lagrutta, A.,Yan, N. Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels. Cell, 185:4801-4810.e13, 2022 Cited by PubMed: 36417914DOI: 10.1016/j.cell.2022.10.024 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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