8E4L
The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2
Summary for 8E4L
Entry DOI | 10.2210/pdb8e4l/pdb |
EMDB information | 27891 |
Descriptor | Transient receptor potential cation channel subfamily M member 8, CALCIUM ION, 3-isothiocyanatoprop-1-ene, ... (5 entities in total) |
Functional Keywords | trpm8, menthol receptor, cold receptor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, membrane protein |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 4 |
Total formula weight | 530778.02 |
Authors | Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.-Y. (deposition date: 2022-08-18, release date: 2022-10-26, Last modification date: 2024-10-16) |
Primary citation | Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.Y. Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378:eadd1268-eadd1268, 2022 Cited by PubMed: 36227998DOI: 10.1126/science.add1268 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.32 Å) |
Structure validation
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