8E4L

The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Transient receptor potential cation channel subfamily M member 8	polymer	1135	131548.3	4	UniProt (Q8R4D5) Pfam (PF18139) Pfam (PF00520) In PDB	Mus musculus (house mouse)	Long transient receptor potential channel 6,LTrpC-6,LTrpC6,Transient receptor potential p8,Trp-p8
2	A, B, C, D	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
3	A, B, C, D	3-isothiocyanatoprop-1-ene	non-polymer		99.2	4	Chemie (UL9)
4	A, B, C, D	nonyl(oxo)di(propan-2-yl)-lambda~5~-phosphane	non-polymer		260.4	4	Chemie (ULO)
5	A, B, C, D	[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate	non-polymer		746.6	4	Chemie (PIO)

Sequence modifications

A, B, C, D: 2 - 1104 (UniProt: Q8R4D5)

PDB	External Database	Details
Met 0	-	expression tag
Ala 1	-	expression tag
Ser 1105	-	expression tag
Asn 1106	-	expression tag
Ser 1107	-	expression tag
Leu 1108	-	expression tag
Glu 1109	-	expression tag
Val 1110	-	expression tag
Leu 1111	-	expression tag
Phe 1112	-	expression tag
Gln 1113	-	expression tag
Gly 1114	-	expression tag
Pro 1115	-	expression tag
Asp 1116	-	expression tag
Tyr 1117	-	expression tag
Lys 1118	-	expression tag
Asp 1119	-	expression tag
Asp 1120	-	expression tag
Asp 1121	-	expression tag
Asp 1122	-	expression tag
Lys 1123	-	expression tag
Ala 1124	-	expression tag
His 1125	-	expression tag
His 1126	-	expression tag
His 1127	-	expression tag
His 1128	-	expression tag
His 1129	-	expression tag
His 1130	-	expression tag
His 1131	-	expression tag
His 1132	-	expression tag
His 1133	-	expression tag
His 1134	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	526193.2
Non-Polymers*	Number of molecules	16
	Total formula weight	4584.8
All*	Total formula weight	530778.0

*Water molecules are not included.