8E08
Crystal structure of HPSE P6 in complex with tetraose pentosan inhibitor
Summary for 8E08
Entry DOI | 10.2210/pdb8e08/pdb |
Descriptor | Heparanase 50 kDa subunit, Heparanase 8 kDa subunit, 2,3,4-tri-O-sulfo-beta-D-xylopyranose-(1-4)-2,3-di-O-sulfo-beta-D-xylopyranose-(1-4)-2,3-di-O-sulfo-beta-D-xylopyranose-(1-4)-2,3-di-O-sulfo-beta-D-xylopyranose, ... (6 entities in total) |
Functional Keywords | heparanase, heparan sulfate, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 57754.75 |
Authors | Whitefield, C.,Jackson, C.J. (deposition date: 2022-08-08, release date: 2023-07-12, Last modification date: 2023-10-25) |
Primary citation | Whitefield, C.,Vo, Y.,Schwartz, B.D.,Hepburn, C.,Ahmed, F.H.,Onagi, H.,Banwell, M.G.,Nelms, K.,Malins, L.R.,Jackson, C.J. Complex Inhibitory Mechanism of Glycomimetics with Heparanase. Biochemistry, 62:2202-2215, 2023 Cited by PubMed: 37368361DOI: 10.1021/acs.biochem.3c00038 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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