8DSZ
PPARg bound to partial agonist H3B-487
Summary for 8DSZ
Entry DOI | 10.2210/pdb8dsz/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2R)-2-{5-[(5-{[(1R)-1-(4-tert-butylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}propanoic acid (3 entities in total) |
Functional Keywords | pparg, partial agonist, h3b-487, nuclear protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 63424.59 |
Authors | Larsen, N.A. (deposition date: 2022-07-24, release date: 2022-09-07, Last modification date: 2023-10-25) |
Primary citation | Irwin, S.,Karr, C.,Furman, C.,Tsai, J.,Gee, P.,Banka, D.,Wibowo, A.S.,Dementiev, A.A.,O'Shea, M.,Yang, J.,Lowe, J.,Mitchell, L.,Ruppel, S.,Fekkes, P.,Zhu, P.,Korpal, M.,Larsen, N.A. Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPAR gamma by inverse agonists. J.Biol.Chem., 298:102539-102539, 2022 Cited by PubMed: 36179791DOI: 10.1016/j.jbc.2022.102539 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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