8DSO
Structure of cIAP1, BTK and BCCov
Summary for 8DSO
Entry DOI | 10.2210/pdb8dso/pdb |
Related | 8DSF |
Descriptor | Tyrosine-protein kinase BTK, Baculoviral IAP repeat-containing protein 2, (4S)-4-[2-(2-{4-[(2E)-4-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}-4-oxobut-2-en-1-yl]piperazin-1-yl}ethoxy)acetamido]-1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-L-prolinamide bound form, ... (5 entities in total) |
Functional Keywords | e3 ligase, protac, ternary complex, btk, oncoprotein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 44605.33 |
Authors | Schiemer, J.S.,Calabrese, M.F. (deposition date: 2022-07-22, release date: 2023-03-08, Last modification date: 2024-05-01) |
Primary citation | Schiemer, J.,Maxwell, A.,Horst, R.,Liu, S.,Uccello, D.P.,Borzilleri, K.,Rajamohan, N.,Brown, M.F.,Calabrese, M.F. A covalent BTK ternary complex compatible with targeted protein degradation. Nat Commun, 14:1189-1189, 2023 Cited by PubMed: 36864023DOI: 10.1038/s41467-023-36738-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.334 Å) |
Structure validation
Download full validation report