8DBN
Human PRPS1-E307A engineered mutation with Phosphate, ATP, and R5P; Hexamer
Summary for 8DBN
Entry DOI | 10.2210/pdb8dbn/pdb |
EMDB information | 27291 |
Descriptor | Ribose-phosphate pyrophosphokinase 1, ADENOSINE-5'-TRIPHOSPHATE, 5-O-phosphono-alpha-D-ribofuranose, ... (4 entities in total) |
Functional Keywords | phosphoribosyl pyrophosphate synthetase, atp/r5p substrate, filament-breaking mutation, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 6 |
Total formula weight | 213377.92 |
Authors | Hvorecny, K.L.,Kollman, J.M. (deposition date: 2022-06-14, release date: 2023-02-15, Last modification date: 2024-06-12) |
Primary citation | Hvorecny, K.L.,Hargett, K.,Quispe, J.D.,Kollman, J.M. Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30:391-402, 2023 Cited by PubMed: 36747094DOI: 10.1038/s41594-023-00921-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.4 Å) |
Structure validation
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