8D3N

Crystal structure of human Apoptosis-Inducing Factor (AIF) complexed with 7-chloroquinolin-4-amine

Summary for 8D3N

• Entry DOI: 10.2210/pdb8d3n/pdb
• Descriptor: Apoptosis-inducing factor 1, mitochondrial, 7-chloroquinolin-4-amine, FLAVIN-ADENINE DINUCLEOTIDE, ... (6 entities in total)
• Functional Keywords: oxidoreductase, mitochondrial import, oxidative phosphorylation, saxs
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 121601.98

Authors

Brosey, C.A.,Tainer, J.A. (deposition date: 2022-06-01, release date: 2023-11-08, Last modification date: 2024-05-29)

• Primary citation: Brosey, C.A.,Link, T.M.,Shen, R.,Moiani, D.,Burnett, K.,Hura, G.L.,Jones, D.E.,Tainer, J.A.; Chemical screening by time-resolved X-ray scattering to discover allosteric probes.; Nat.Chem.Biol., 2024; PubMed: 38671223; DOI: 10.1038/s41589-024-01609-1

Experimental method

X-RAY DIFFRACTION (2.25 Å)