8CVQ
Crystal structure of TDP1 complexed with compound XZ761
Summary for 8CVQ
Entry DOI | 10.2210/pdb8cvq/pdb |
Descriptor | Tyrosyl-DNA phosphodiesterase 1, 4-{[(4S)-2,7-diphenylimidazo[1,2-a]pyridin-3-yl]amino}benzene-1,2-dicarboxylic acid, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, dna binding protein, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 106004.59 |
Authors | Lountos, G.T.,Zhao, X.Z.,Wang, W.,Kiselev, E.,Tropea, J.E.,Needle, D.,Pommier, Y.,Burke, T.R. (deposition date: 2022-05-18, release date: 2023-04-12, Last modification date: 2023-10-25) |
Primary citation | Zhao, X.Z.,Wang, W.,Lountos, G.T.,Kiselev, E.,Tropea, J.E.,Needle, D.,Pommier, Y.,Burke Jr., T.R. Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification. Rsc Chem Biol, 4:334-343, 2023 Cited by PubMed: 37181631DOI: 10.1039/d2cb00230b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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