8CF3

Crystal structure of S. aureus BlaR1 sensor domain in complex with cefepime

Summary for 8CF3

• Entry DOI: 10.2210/pdb8cf3/pdb
• Related: 8C0P 8C0S
• Descriptor: Regulatory protein BlaR1, Cefepime (open) (3 entities in total)
• Functional Keywords: antibiotic resistance, beta-lactam sensor of staphylococcus aureus, mrsa, signaling protein
• Biological source: Staphylococcus aureus; More
• Total number of polymer chains: 2
• Total formula weight: 59885.44

Authors

Miguel-Ruano, V.,Hermoso, J.A. (deposition date: 2023-02-02, release date: 2024-09-04)

• Primary citation: Nguyen, V.T.,Birhanu, B.T.,Miguel-Ruano, V.,Kim, C.,Batuecas, M.,Yang, J.,El-Araby, A.M.,Jimenez-Faraco, E.,Schroeder, V.A.,Alba, A.,Rana, N.,Sader, S.,Thomas, C.A.,Feltzer, R.,Lee, M.,Fisher, J.F.,Hermoso, J.A.,Chang, M.,Mobashery, S.; Restoring susceptibility to beta-lactam antibiotics in methicillin-resistant Staphylococcus aureus.; Nat.Chem.Biol., 2024; PubMed: 39060390; DOI: 10.1038/s41589-024-01688-0

Experimental method

X-RAY DIFFRACTION (2.52 Å)