8C0P
Crystal structure of S. aureus BlaR1 sensor domain in complex with a boronate inhibitor
Summary for 8C0P
Entry DOI | 10.2210/pdb8c0p/pdb |
Descriptor | Regulatory protein BlaR1, [1-[[2,4-bis(trifluoromethyl)phenyl]methyl]benzimidazol-2-yl]sulfanylmethyl-$l^{3}-oxidanyl-bis(oxidanyl)boron (3 entities in total) |
Functional Keywords | antibiotic resistance, beta-lactam sensor of staphylococcus aureus, mrsa, signaling protein |
Biological source | Staphylococcus aureus More |
Total number of polymer chains | 2 |
Total formula weight | 60443.21 |
Authors | Miguel-Ruano, V.,Jimenez-Faraco, E.,Hermoso, J.A. (deposition date: 2022-12-19, release date: 2024-07-10) |
Primary citation | Miguel-Ruano, V.,Jimenez Faraco, E.,Alba-Perez, A.,Hermoso, J.A. Restoring Susceptibility to b-Lactam Antibiotics in Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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