8CEW

Crystal structure of human DNA cross-link repair 1A in complex with N-hydroxyimide inhibitor H1

Summary for 8CEW

Entry DOI	10.2210/pdb8cew/pdb
Descriptor	DNA cross-link repair 1A protein, DIMETHYL SULFOXIDE, NICKEL (II) ION, ... (6 entities in total)
Functional Keywords	snm1a, nuclease inhibition, icl, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	39829.00
Authors	Newman, J.A.,Yosaatmadja, Y.,Baddock, H.T.,Bielinski, M.,von Delft, F.,Bountra, C.,McHugh, P.J.,Schofield, C.J.,Gileadi, O. (deposition date: 2023-02-02, release date: 2024-02-21, Last modification date: 2024-09-11)
Primary citation	Bielinski, M.,Henderson, L.R.,Yosaatmadja, Y.,Swift, L.P.,Baddock, H.T.,Bowen, M.J.,Brem, J.,Jones, P.S.,McElroy, S.P.,Morrison, A.,Speake, M.,van Boeckel, S.,van Doornmalen, E.,van Groningen, J.,van den Hurk, H.,Gileadi, O.,Newman, J.A.,McHugh, P.J.,Schofield, C.J. Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target. Chem Sci, 15:8227-8241, 2024 Cited by PubMed: 38817593 DOI: 10.1039/d4sc00367e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation