8CEW
Crystal structure of human DNA cross-link repair 1A in complex with N-hydroxyimide inhibitor H1
Summary for 8CEW
Entry DOI | 10.2210/pdb8cew/pdb |
Descriptor | DNA cross-link repair 1A protein, DIMETHYL SULFOXIDE, NICKEL (II) ION, ... (6 entities in total) |
Functional Keywords | snm1a, nuclease inhibition, icl, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 39829.00 |
Authors | Newman, J.A.,Yosaatmadja, Y.,Baddock, H.T.,Bielinski, M.,von Delft, F.,Bountra, C.,McHugh, P.J.,Schofield, C.J.,Gileadi, O. (deposition date: 2023-02-02, release date: 2024-02-21, Last modification date: 2024-09-11) |
Primary citation | Bielinski, M.,Henderson, L.R.,Yosaatmadja, Y.,Swift, L.P.,Baddock, H.T.,Bowen, M.J.,Brem, J.,Jones, P.S.,McElroy, S.P.,Morrison, A.,Speake, M.,van Boeckel, S.,van Doornmalen, E.,van Groningen, J.,van den Hurk, H.,Gileadi, O.,Newman, J.A.,McHugh, P.J.,Schofield, C.J. Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target. Chem Sci, 15:8227-8241, 2024 Cited by PubMed: 38817593DOI: 10.1039/d4sc00367e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)