8C8C

Crystal Structure of Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PI5P4Ka) bound to an inhibitor

Summary for 8C8C

• Entry DOI: 10.2210/pdb8c8c/pdb
• Descriptor: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, ~{N}-(3-chloranyl-4-methoxy-phenyl)-7-(3,4-dimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine (3 entities in total)
• Functional Keywords: inhibitor, atp, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 43238.24

Authors

Harborne, S.P.D.,Howard, T.D.,Ogg, D.T. (deposition date: 2023-01-19, release date: 2023-04-26, Last modification date: 2024-06-19)

• Primary citation: Willems, H.M.G.,Edwards, S.,Boffey, H.K.,Chawner, S.J.,Green, C.,Romero, T.,Winpenny, D.,Skidmore, J.,Clarke, J.H.,Andrews, S.P.; Identification of ARUK2002821 as an isoform-selective PI5P4K alpha inhibitor.; Rsc Med Chem, 14:934-946, 2023; PubMed: 37252102; DOI: 10.1039/d3md00039g

Experimental method

X-RAY DIFFRACTION (2.096 Å)