8C86
Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 2
Summary for 8C86
Entry DOI | 10.2210/pdb8c86/pdb |
Related | 6SUH |
Descriptor | Transthyretin, (2,4-dimethylphenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone (3 entities in total) |
Functional Keywords | amyloidosis, tetramer, binding protein, transport protein, lipid binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 28159.32 |
Authors | Poonsiri, T.,Benini, S.,Loconte, V.,Cianci, M. (deposition date: 2023-01-18, release date: 2024-01-17, Last modification date: 2024-01-24) |
Primary citation | Poonsiri, T.,Dell'Accantera, D.,Loconte, V.,Casnati, A.,Cervoni, L.,Arcovito, A.,Benini, S.,Ferrari, A.,Cipolloni, M.,Cacioni, E.,De Franco, F.,Giacche, N.,Rinaldo, S.,Folli, C.,Sansone, F.,Berni, R.,Cianci, M. 3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity. Int J Mol Sci, 25:-, 2023 Cited by PubMed: 38203650DOI: 10.3390/ijms25010479 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
Download full validation report