8C2Z

Crystal structure of DYRK1B in complex with AZ191

Summary for 8C2Z

• Entry DOI: 10.2210/pdb8c2z/pdb
• Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 1B, N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine, MANGANESE (II) ION, ... (4 entities in total)
• Functional Keywords: kinase, diabetes, kinase inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 43498.45

Authors

Grygier, P.,Pustelny, K.,Dubin, G.,Czarna, A. (deposition date: 2022-12-23, release date: 2024-01-17, Last modification date: 2024-10-16)

• Primary citation: Grygier, P.,Pustelny, K.,Dubin, G.,Czarna, A.; Structural perspective on the design of selective DYRK1B inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.91 Å)