8C2Z
Crystal structure of DYRK1B in complex with AZ191
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | polymer | 372 | 42904.1 | 1 | UniProt (Q9Y463) Pfam (PF00069) In PDB | Homo sapiens (human) | Minibrain-related kinase,Mirk protein kinase |
2 | A | N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine | non-polymer | 429.5 | 1 | Chemie (QS0) | |||
3 | A | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) | |||
4 | water | water | 18.0 | 185 | Chemie (HOH) |
Sequence modifications
A: 78 - 442 (UniProt: Q9Y463)
PDB | External Database | Details |
---|---|---|
Met 77 | - | initiating methionine |
Glu 443 | - | expression tag |
Asn 444 | - | expression tag |
Leu 445 | - | expression tag |
Tyr 446 | - | expression tag |
Phe 447 | - | expression tag |
Gln 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 42904.1 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 594.3 | |
All* | Total formula weight | 43498.5 |