8C2Z
Crystal structure of DYRK1B in complex with AZ191
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | polymer | 372 | 42904.1 | 1 | UniProt (Q9Y463) Pfam (PF00069) | Homo sapiens (human) | Minibrain-related kinase,Mirk protein kinase |
| 2 | B (A) | N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine | non-polymer | 429.5 | 1 | Chemie (QS0) | |||
| 3 | C, D, E (A) | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) | |||
| 4 | F (A) | water | water | 18.0 | 185 | Chemie (HOH) |
Sequence modifications
A: 78 - 442 (UniProt: Q9Y463)
| PDB | External Database | Details |
|---|---|---|
| Met 77 | - | initiating methionine |
| Glu 443 | - | expression tag |
| Asn 444 | - | expression tag |
| Leu 445 | - | expression tag |
| Tyr 446 | - | expression tag |
| Phe 447 | - | expression tag |
| Gln 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42904.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 594.3 | |
| All* | Total formula weight | 43498.5 |
