8C15

Aurora A kinase in complex with TPX2-inhibitor 3

Summary for 8C15

Entry DOI	10.2210/pdb8c15/pdb
Descriptor	Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (9 entities in total)
Functional Keywords	protein-ligand complex, kinase, protein-protein interaction inhibitor, tpx2, cell cycle
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	32461.70
Authors	Fischer, G.,Rocaboy, M.,Blaszczyk, B.,Moschetti, T.,Wang, X.,Scott, D.E.,Coyne, A.G.,Dagostin, C.,Rooney, T.,Bayly, A.,Feng, J.,Asteian, A.,Alcaide-Lopez, A.,Stockwell, S.,Skidmore, J.,Venkitaraman, A.R.,Abell, C.,Blundell, T.L.,Hyvonen, M. (deposition date: 2022-12-20, release date: 2024-01-10, Last modification date: 2024-09-04)
Primary citation	Stockwell, S.R.,Scott, D.E.,Fischer, G.,Guarino, E.,Rooney, T.P.C.,Feng, T.S.,Moschetti, T.,Srinivasan, R.,Alza, E.,Asteian, A.,Dagostin, C.,Alcaide, A.,Rocaboy, M.,Blaszczyk, B.,Higueruelo, A.,Wang, X.,Rossmann, M.,Perrior, T.R.,Blundell, T.L.,Spring, D.R.,McKenzie, G.,Abell, C.,Skidmore, J.,Venkitaraman, A.R.,Hyvonen, M. Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents. J.Med.Chem., 2024 Cited by PubMed: 39190548 DOI: 10.1021/acs.jmedchem.4c01165 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation