8C0C
X-ray crystal structure of PPAR gamma ligand binding domain in complex with CZ46
Summary for 8C0C
Entry DOI | 10.2210/pdb8c0c/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2~{R})-2-[4-(naphthalen-1-ylmethoxy)phenyl]-4-oxidanyl-3-phenyl-2~{H}-furan-5-one (3 entities in total) |
Functional Keywords | ppar, nuclear receptor, transcription, nuclear protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 69247.91 |
Authors | Capelli, D.,Montanari, R.,Pochetti, G.,Villa, S.,Meneghetti, F. (deposition date: 2022-12-16, release date: 2023-04-26, Last modification date: 2024-06-19) |
Primary citation | Capelli, D.,Cazzaniga, G.,Mori, M.,Laghezza, A.,Loiodice, F.,Quaglia, M.,Negro, E.,Meneghetti, F.,Villa, S.,Montanari, R. Biological Screening and Crystallographic Studies of Hydroxy gamma-Lactone Derivatives to Investigate PPAR gamma Phosphorylation Inhibition. Biomolecules, 13:-, 2023 Cited by PubMed: 37189440DOI: 10.3390/biom13040694 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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