8C0C
X-ray crystal structure of PPAR gamma ligand binding domain in complex with CZ46
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Peroxisome proliferator-activated receptor gamma | polymer | 303 | 34419.7 | 2 | UniProt (P37231) Pfam (PF00104) In PDB | Homo sapiens (human) | PPAR-gamma,Nuclear receptor subfamily 1 group C member 3 |
2 | B | (2~{R})-2-[4-(naphthalen-1-ylmethoxy)phenyl]-4-oxidanyl-3-phenyl-2~{H}-furan-5-one | non-polymer | 408.4 | 1 | Chemie (T0C) | |||
3 | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A, B: 195 - 476 (UniProt: P37231)
PDB | External Database | Details |
---|---|---|
Met 174 | - | initiating methionine |
Gly 175 | - | expression tag |
Ser 176 | - | expression tag |
Ser 177 | - | expression tag |
His 178 | - | expression tag |
His 179 | - | expression tag |
His 180 | - | expression tag |
His 181 | - | expression tag |
His 182 | - | expression tag |
His 183 | - | expression tag |
Ser 184 | - | expression tag |
Ser 185 | - | expression tag |
Gly 186 | - | expression tag |
Leu 187 | - | expression tag |
Val 188 | - | expression tag |
Pro 189 | - | expression tag |
Arg 190 | - | expression tag |
Gly 191 | - | expression tag |
Ser 192 | - | expression tag |
His 193 | - | expression tag |
Met 194 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 68839.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 408.4 | |
All* | Total formula weight | 69247.9 |