8BZX

1-deoxy-D-xylulose 5-phosphate synthase from Klebsiella pneumoniae (kpDXPS),co-crystal with thiamine monophosphate analog

Summary for 8BZX

Entry DOI	10.2210/pdb8bzx/pdb
Descriptor	1-deoxy-D-xylulose-5-phosphate synthase, 2-[4-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-3-methyl-5-propanoyl-thiophen-2-yl]ethyl dihydrogen phosphate, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	1-deoxy-d-xylulose 5-phosphate synthase, klebsiella pneumoniae, thiamine monophosphate, transferase
Biological source	Klebsiella pneumoniae More
Total number of polymer chains	2
Total formula weight	127379.97
Authors	Hamid, R. (deposition date: 2022-12-15, release date: 2023-06-14, Last modification date: 2024-06-19)
Primary citation	Chan, A.H.Y.,Ho, T.C.S.,Irfan, R.,Hamid, R.A.A.,Rudge, E.S.,Iqbal, A.,Turner, A.,Hirsch, A.K.H.,Leeper, F.J. Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation. Bioorg.Chem., 138:106602-106602, 2023 Cited by PubMed: 37201323 DOI: 10.1016/j.bioorg.2023.106602 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation