8BDT
Ternary complex between VCB, BRD4-BD2 and PROTAC 51
Summary for 8BDT
Entry DOI | 10.2210/pdb8bdt/pdb |
Descriptor | Bromodomain-containing protein 4, Elongin-B, Elongin-C, ... (7 entities in total) |
Functional Keywords | protac, vhl, vcb, complex, ternary complex, degrader, e3 ligase, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 114946.37 |
Authors | Sorrell, F.J.,Mueller, J.E.,Lehmann, M.,Wegener, A.A. (deposition date: 2022-10-20, release date: 2023-02-15, Last modification date: 2024-02-07) |
Primary citation | Krieger, J.,Sorrell, F.J.,Wegener, A.A.,Leuthner, B.,Machrouhi-Porcher, F.,Hecht, M.,Leibrock, E.M.,Muller, J.E.,Eisert, J.,Hartung, I.V.,Schlesiger, S. Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design. Chemmedchem, 18:e202200615-e202200615, 2023 Cited by PubMed: 36749883DOI: 10.1002/cmdc.202200615 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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