8BDT
Ternary complex between VCB, BRD4-BD2 and PROTAC 51
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Bromodomain-containing protein 4 | polymer | 129 | 14899.1 | 2 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (human) | Protein HUNK1 |
| 2 | B, F (B, F) | Elongin-B | polymer | 104 | 11748.4 | 2 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 3 | C, G (C, G) | Elongin-C | polymer | 97 | 10974.6 | 2 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 4 | D, H (D, H) | von Hippel-Lindau disease tumor suppressor | polymer | 162 | 18702.3 | 2 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (human) | Protein G7,pVHL |
| 5 | I, K (D, H) | (2~{S},4~{R})-~{N}-[(1~{S})-3-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethylamino]-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-3-oxidanylidene-propyl]-1-[(2~{R})-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide | non-polymer | 1097.7 | 2 | Chemie (QLX) | |||
| 6 | J (G) | MALONATE ION | non-polymer | 102.0 | 1 | Chemie (MLI) | |||
| 7 | L, M, N, O, P... (A, B, C, D, E...) | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
A, E: 333 - 460 (UniProt: O60885)
C, G: 17 - 112 (UniProt: Q15369)
D, H: 54 - 213 (UniProt: P40337)
| PDB | External Database | Details |
|---|---|---|
| Gly 332 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 112648.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 2297.5 | |
| All* | Total formula weight | 114946.4 |
