8AYN
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand LY3130481
Summary for 8AYN
Entry DOI | 10.2210/pdb8ayn/pdb |
EMDB information | 15717 |
Descriptor | Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-8 subunit, Isoform Flip of Glutamate receptor 1, ... (8 entities in total) |
Functional Keywords | ampar, ion channels, neurotransmission, membrane protein |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 6 |
Total formula weight | 495428.27 |
Authors | Zhang, D.,Lape, R.,Shaikh, S.,Kohegyi, B.,Watson, J.F.,Cais, O.,Nakagawa, T.,Greger, I.H. (deposition date: 2022-09-02, release date: 2023-04-19) |
Primary citation | Zhang, D.,Lape, R.,Shaikh, S.A.,Kohegyi, B.K.,Watson, J.F.,Cais, O.,Nakagawa, T.,Greger, I.H. Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics. Nat Commun, 14:1659-1659, 2023 Cited by PubMed: 36966141DOI: 10.1038/s41467-023-37259-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.8 Å) |
Structure validation
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