8AYN
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand LY3130481
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, D | Isoform Flip of Glutamate receptor 2 | polymer | 860 | 96247.1 | 2 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Norway rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | I, J | Voltage-dependent calcium channel gamma-8 subunit | polymer | 423 | 43576.0 | 2 | UniProt (Q8VHW5) Pfam (PF00822) In PDB | Rattus norvegicus (Norway rat) | Neuronal voltage-gated calcium channel gamma-8 subunit,Transmembrane AMPAR regulatory protein gamma-8,TARP gamma-8 |
| 3 | C, A | Isoform Flip of Glutamate receptor 1 | polymer | 915 | 102661.9 | 2 | UniProt (P19490) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Norway rat) | GluR-1,AMPA-selective glutamate receptor 1,GluR-A,GluR-K1,Glutamate receptor ionotropic,AMPA 1,GluA1 |
| 4 | A, B, D, C | {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | non-polymer | 409.3 | 4 | Chemie (ZK1) | |||
| 5 | A, B, D, C | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 4 | Chemie (OLC) | |||
| 6 | A, B, I, J, D... | PALMITIC ACID | non-polymer | 256.4 | 14 | Chemie (PLM) | |||
| 7 | C, A, B, D | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 4 | Chemie (POV) | |||
| 8 | I, J | 6-[(1~{S})-1-[1-[5-(2-hydroxyethyloxy)pyridin-2-yl]pyrazol-3-yl]ethyl]-3~{H}-1,3-benzothiazol-2-one | non-polymer | 382.4 | 2 | Chemie (OLR) |
Sequence modifications
B, D: -20 - 839 (UniProt: P19491)
I, J: 2 - 417 (UniProt: Q8VHW5)
C, A: -25 - 889 (UniProt: P19490)
| PDB | External Database | Details |
|---|---|---|
| Arg 586 | Gln 607 | variant |
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Leu 418 | - | expression tag |
| Glu 419 | - | expression tag |
| Val 420 | - | expression tag |
| Leu 421 | - | expression tag |
| Phe 422 | - | expression tag |
| Gln 423 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp -6 | - | insertion |
| Tyr -5 | - | insertion |
| Lys -4 | - | insertion |
| Asp -3 | - | insertion |
| Asp -2 | - | insertion |
| Asp -1 | - | insertion |
| Asp 0 | - | insertion |
| Lys 1 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 484970.0 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 10458.3 | |
| All* | Total formula weight | 495428.3 |
