8AUP
Structure of hARG1 with a novel inhibitor.
Summary for 8AUP
Entry DOI | 10.2210/pdb8aup/pdb |
Descriptor | Arginase-1, MANGANESE (II) ION, 2-[(1~{R},3~{R},4~{S})-3-azanyl-3-carboxy-4-[(dimethylamino)methyl]cyclohexyl]ethyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, ... (6 entities in total) |
Functional Keywords | protein-inhibitor complex, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 6 |
Total formula weight | 211315.86 |
Authors | Napiorkowska-Gromadzka, A.,Nowak, E.,Nowotny, M. (deposition date: 2022-08-25, release date: 2023-03-29, Last modification date: 2024-02-07) |
Primary citation | Borek, B.,Nowicka, J.,Gzik, A.,Dziegielewski, M.,Jedrzejczak, K.,Brzezinska, J.,Grzybowski, M.,Stanczak, P.,Pomper, P.,Zagozdzon, A.,Rejczak, T.,Matyszewski, K.,Golebiowski, A.,Olczak, J.,Lisiecki, K.,Tyszkiewicz, M.,Kania, M.,Piasecka, S.,Cabaj, A.,Dera, P.,Mulewski, K.,Chrzanowski, J.,Kusmirek, D.,Sobolewska, E.,Magdycz, M.,Mucha, L.,Masnyk, M.,Golab, J.,Nowotny, M.,Nowak, E.,Napiorkowska-Gromadzka, A.,Pikul, S.,Jazwiec, R.,Dzwonek, K.,Dobrzanski, P.,Meyring, M.,Skowronek, K.,Iwanowski, P.,Zaslona, Z.,Blaszczyk, R. Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy. Mol.Cancer Ther., 22:807-817, 2023 Cited by PubMed: 36939275DOI: 10.1158/1535-7163.MCT-22-0721 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.17 Å) |
Structure validation
Download full validation report