8AEU
Structure of hMDM2 in complex with Nutlin-3a-aa
Summary for 8AEU
Entry DOI | 10.2210/pdb8aeu/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, BETA-MERCAPTOETHANOL, 4-[[(4~{S},5~{R})-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxy-phenyl)-4,5-dihydroimidazol-1-yl]carbonyl]-3-methylidene-piperazin-2-one, ... (4 entities in total) |
Functional Keywords | biological activity, drug design, inhibitors, protein-protein interactions, ligase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 12071.01 |
Authors | Labuzek, B.,Golik, P.,Magiera-Mularz, K.,Berg, T. (deposition date: 2022-07-13, release date: 2023-01-18, Last modification date: 2024-02-07) |
Primary citation | Nietzold, F.,Rubner, S.,Labuzek, B.,Golik, P.,Surmiak, E.,Del Corte, X.,Kitel, R.,Protzel, C.,Reppich-Sacher, R.,Stichel, J.,Magiera-Mularz, K.,Holak, T.A.,Berg, T. Nutlin-3a-aa: Improving the Bioactivity of a p53/MDM2 Interaction Inhibitor by Introducing a Solvent-Exposed Methylene Group. Chembiochem, 24:e202300006-e202300006, 2023 Cited by PubMed: 36602436DOI: 10.1002/cbic.202300006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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