8AEU
Structure of hMDM2 in complex with Nutlin-3a-aa
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | E3 ubiquitin-protein ligase Mdm2 | polymer | 97 | 11399.4 | 1 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
| 2 | B (A) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 3 | C (A) | 4-[[(4~{S},5~{R})-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxy-phenyl)-4,5-dihydroimidazol-1-yl]carbonyl]-3-methylidene-piperazin-2-one | non-polymer | 593.5 | 1 | Chemie (M0L) | |||
| 4 | D (A) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A: 2 - 97 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 11399.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 671.6 | |
| All* | Total formula weight | 12071.0 |
