8ADJ

Poly(ADP-ribose) glycohydrolase (PARG) from Drosophila melanogaster in complex with PARG inhibitor PDD00017272

Summary for 8ADJ

• Entry DOI: 10.2210/pdb8adj/pdb
• Descriptor: Poly(ADP-ribose) glycohydrolase, 1-[(2,5-dimethylpyrazol-3-yl)methyl]-N-(1-methylcyclopropyl)-3-[(2-methyl-1,3-thiazol-5-yl)methyl]-2,4-bis(oxidanylidene)quinazoline-6-sulfonamide, GLYCEROL, ... (6 entities in total)
• Functional Keywords: parg, poly(adp-ribose) glycohydrolase, inhibitor, pdd00017272, hydrolase
• Biological source: Drosophila melanogaster (fruit fly)
• Total number of polymer chains: 3
• Total formula weight: 200667.99

Authors

Ariza, A.,Fontana, P. (deposition date: 2022-07-08, release date: 2023-06-14, Last modification date: 2024-02-07)

• Primary citation: Fontana, P.,Buch-Larsen, S.C.,Suyari, O.,Smith, R.,Suskiewicz, M.J.,Schutzenhofer, K.,Ariza, A.,Rack, J.G.M.,Nielsen, M.L.,Ahel, I.; Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling.; Nat Commun, 14:3200-3200, 2023; PubMed: 37268618; DOI: 10.1038/s41467-023-38793-y

Experimental method

X-RAY DIFFRACTION (2.508 Å)