8ADJ
Poly(ADP-ribose) glycohydrolase (PARG) from Drosophila melanogaster in complex with PARG inhibitor PDD00017272
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004649 | molecular_function | poly(ADP-ribose) glycohydrolase activity |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006282 | biological_process | regulation of DNA repair |
| B | 0004649 | molecular_function | poly(ADP-ribose) glycohydrolase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006282 | biological_process | regulation of DNA repair |
| C | 0004649 | molecular_function | poly(ADP-ribose) glycohydrolase activity |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006282 | biological_process | regulation of DNA repair |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 375 |
| Details | Domain: {"description":"PARG helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 600 |
| Details | Domain: {"description":"PARG catalytic Macro","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"I6L8L7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"I6L8L7","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"37268618","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"I6L8L7","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"37268618","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18327897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34949666","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
