7ZZ7

Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a linear di-adenosine derivative

Summary for 7ZZ7

• Entry DOI: 10.2210/pdb7zz7/pdb
• Descriptor: NAD kinase 1, CITRIC ACID, 2-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-[6-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-[(2-azanylethanoylamino)methyl]-3,4-bis(oxidanyl)oxolan-2-yl]purin-8-yl]prop-2-ynyl]amino]ethanoic acid, ... (4 entities in total)
• Functional Keywords: tetrameric nad-kinase, transferase
• Biological source: Listeria monocytogenes EGD-e
• Total number of polymer chains: 1
• Total formula weight: 31921.04

Authors

Gelin, M.,Labesse, G. (deposition date: 2022-05-25, release date: 2023-01-11, Last modification date: 2024-01-31)

• Primary citation: Clement, D.A.,Gelin, M.,Leseigneur, C.,Huteau, V.,Mondange, L.,Pons, J.L.,Dussurget, O.,Lionne, C.,Labesse, G.,Pochet, S.; Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria.; Eur.J.Med.Chem., 246:114941-114941, 2023; PubMed: 36455355; DOI: 10.1016/j.ejmech.2022.114941

Experimental method

X-RAY DIFFRACTION (2 Å)