7ZYS

Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2227

Summary for 7ZYS

Entry DOI	10.2210/pdb7zys/pdb
Descriptor	Serine protease subunit NS2B, Serine protease NS3, 1-[(8~{R},15~{S},18~{S})-18-(4-azanylbutyl)-15-butyl-4,7,14,17,20-pentakis(oxidanylidene)-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(26),22,24-trien-8-yl]guanidine, ... (4 entities in total)
Functional Keywords	flavivirin, serine protease, viral protein, ns2b-ns3, zika virus
Biological source	Zika virus More
Total number of polymer chains	2
Total formula weight	25518.74
Authors	Huber, S.,Steinmetzer, T. (deposition date: 2022-05-25, release date: 2022-07-13, Last modification date: 2024-06-12)
Primary citation	Huber, S.,Braun, N.J.,Schmacke, L.C.,Murra, R.,Bender, D.,Hildt, E.,Heine, A.,Steinmetzer, T. Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B-NS3 protease. Arch Pharm, :e2400250-e2400250, 2024 Cited by PubMed: 38809037 DOI: 10.1002/ardp.202400250 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.26 Å)

Structure validation