7ZYM
Crystal Structure of EGFR-T790M/C797S in Complex with Brigatinib
Summary for 7ZYM
| Entry DOI | 10.2210/pdb7zym/pdb |
| Descriptor | Epidermal growth factor receptor, 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine (3 entities in total) |
| Functional Keywords | egfr, t790m/c797s, inhibitor, transferase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 38299.70 |
| Authors | Niggenaber, J.,Kleinboelting, S.,Mueller, M.P.,Rauh, D. (deposition date: 2022-05-25, release date: 2023-05-03, Last modification date: 2024-02-07) |
| Primary citation | Grabe, T.,Jeyakumar, K.,Niggenaber, J.,Schulz, T.,Koska, S.,Kleinbolting, S.,Beck, M.E.,Muller, M.P.,Rauh, D. Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines. Acs Med.Chem.Lett., 14:591-598, 2023 Cited by PubMed: 37197473DOI: 10.1021/acsmedchemlett.2c00514 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report
