7ZYM
Crystal Structure of EGFR-T790M/C797S in Complex with Brigatinib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 333 | 37715.6 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | A | 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine | non-polymer | 584.1 | 1 | Chemie (6GY) | |||
3 | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 690 | - | expression tag |
Ser 691 | - | expression tag |
His 692 | - | expression tag |
Met 693 | - | expression tag |
Ala 694 | - | expression tag |
Met 790 | Thr 790 | engineered mutation |
Ser 797 | Cys 797 | engineered mutation |
Ala 865 | Glu 865 | engineered mutation |
Ala 866 | Glu 866 | engineered mutation |
Ala 867 | Lys 867 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37715.6 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 584.1 | |
All* | Total formula weight | 38299.7 |