7ZYK

Compound 9 Bound to CK2alpha

Summary for 7ZYK

Entry DOI	10.2210/pdb7zyk/pdb
Descriptor	Casein kinase II subunit alpha, ADENOSINE-5'-DIPHOSPHATE, 2-(5-bromanyl-6-chloranyl-1~{H}-indol-3-yl)ethanenitrile, ... (5 entities in total)
Functional Keywords	fragment based drug discovery, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	39964.29
Authors	Brear, P.,Hyvonen, M. (deposition date: 2022-05-25, release date: 2022-12-07, Last modification date: 2024-01-31)
Primary citation	Brear, P.,De Fusco, C.,Atkinson, E.L.,Iegre, J.,Francis-Newton, N.J.,Venkitaraman, A.R.,Hyvonen, M.,Spring, D.R. A fragment-based approach leading to the discovery of inhibitors of CK2 alpha with a novel mechanism of action. Rsc Med Chem, 13:1420-1426, 2022 Cited by PubMed: 36426237 DOI: 10.1039/d2md00161f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.31 Å)

Structure validation