7ZY0

Crystal structure of compound 7 bound to CK2alpha

Summary for 7ZY0

Entry DOI	10.2210/pdb7zy0/pdb
Descriptor	Casein kinase II subunit alpha, 2-(5-bromanyl-1~{H}-indol-3-yl)ethanenitrile, ADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	fragment based drug discovery, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	39693.67
Authors	Brear, P.,Fusco, C.,Atkinson, E.,Rossmann, M.,Francis, N.,Iegre, J.,Hyvonen, M.,Spring, D. (deposition date: 2022-05-23, release date: 2022-10-12, Last modification date: 2024-02-07)
Primary citation	Brear, P.,De Fusco, C.,Atkinson, E.L.,Iegre, J.,Francis-Newton, N.J.,Venkitaraman, A.R.,Hyvonen, M.,Spring, D.R. A fragment-based approach leading to the discovery of inhibitors of CK2 alpha with a novel mechanism of action. Rsc Med Chem, 13:1420-1426, 2022 Cited by PubMed: 36426237 DOI: 10.1039/d2md00161f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.44 Å)

Structure validation